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Lets look at the main factors to consider: Bioavailability Traditionally, injection has been considered the most efficient route of administering peptide drugs due to their instability and rapid degradation with oral, topical, and other delivery methods

Yin, X., Yin, Y., Cao, F

Neuroscience Letters, 675(1), 96101

In UK practice, monitoring is primarily based on clinical response rather than routine blood tests, as post-treatment serum B12 measurements can be misleadingly high and may not reflect tissue levels
