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Besides mitochondria, cytoplasmic ROS is generated by NOXs, which is also an important source of ROS in T cell

Studies have been done in human microvascular endothelial cells (HMVECs), HUVECs, and cultured endothelial cells with varying effects on VEGF receptors (Zingg, 2019)

Thus, during exercise, cells move to a mode of quickly cycling between reduced electron carriers (NADH/FADH2) and oxidized electron carriers (NAD+/FAD)