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10.1007/s00403-022-02339-x 88

Another case series enrolled 30 Chinese women with melasma, who took 25 mg pycnogenol three times daily for 30 days, leading to a 32% mean area reduction and a 22% intensity reduction of facial melasma [86]

RVG29, a new type of RMT-targeting peptide, can specifically recognize nicotinic acetylcholine receptors, which not only show high expression in ECs but also in astrocytes, microglia, and dopaminergic neurons
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