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There exists a long list of other conditions, disorders, and complications related to vitamin B-12 deficiency, and on which the research remains unclear/inconclusive, but has shown some improvement during vitamin B-12 supplementation including: [7][8][9] Alzheimers disease, Angioplasty (opening narrowed/blocked arteries), Breast cancer, Canker sores, Cardiovascular disease/hyperhomocysteinemia, Cervical cancer, Claudication (leg pain from clogged arteries), Depression, Diabetic neuropathy (nerve damage), Diagnostic procedure, Facial spasm, Fatigue, Fractures (prevention), High cholesterol, Imerslund-Grasbeck disease, Joint pain (elbow), Mental performance, Poisoning (cyanide), Shaky-leg syndrome, Sickle cell disease, Sleep disorders (circadian rhythm) Vitamin B-12 Sources and Treatments Vitamin B-12 is necessary to produce an adequate amount of healthy red blood cells in the bone marrow, is available only in animal foods (meat and dairy products) or yeast extracts (such as brewers yeast)