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Description
The strong protective effect of lipophilic antioxidants, such as vitamin E, is likely due to their ability to suppress the formation and propagation of oxidized lipids upon GPX4 inhibition
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Neurotoxicity is apparently dose-dependent (frequent for 250350 mg/m 2 , almost certain if dosage exceeds 500600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]
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