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Reactivation is often spontaneous, but can also be triggered by immune suppression or alterations in immune function and after cancer chemotherapy (61)
Liu B, Zhu L, Wang M, et al
Autopsy samples from individuals with secondary progressive MS (SPMS) showed NCOA4 expression in macrophages and oligodendrocytes at the mixed active/non-active lesion edge, with iron ferritin-positive cells and iron-containing cells present in this region
Camaschella C, Campanella A, De Falco L, Boschetto L, Merlini R, Silvestri L, et al
