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Journal of Applied Physiology (2011) 4

The balanced conclusion: optimizing B12 is a high-upside, low-risk move for anyone with low or low-normal levels and mood symptoms

Quality of Individual Studies and Determination of Evidence Strength Quality of individual studies that were RCTs or crossover trials was assessed using the Cochrane Risk of Bias tool
I get this question often from clinicians and patients ask me what I mean when I say there is no human safety data