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These oxidized clusters serve as senescence indicators, directing RBCs for macrophage-mediated elimination and leading to hemolytic disorders (34, 35)

There is a need to develop safer, more reliable, and universal platforms for delivering functional biomolecules into intact plants for a wide range of applications in plant biotechnology ( Nanoparticle-mediated delivery of biomolecules has already had an immense impact in the biomedical field (Yong et al., 2025)

As shown in Table 1, with regard to the association of MTHFR gene and its enzyme products, some of the studies revealed severe enzymatic deficiency