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The treadmill training protocol was performed for 1 h daily on an EXER-4 treadmill (Columbus Instruments, Columbus, OH, United States) as described before ( At the end of the training period, the animals were sacrificed, and the liver and kidneys were quickly excised from the animals and stored immediately at 80C until further analysis (within 1 week)

Pooled studies were homogenous ( 2 P = .95, I 2 = 0%)

Draw volume for a 150 mcg dose: 0.150 mg 3.33 mg/mL = 0.045 mL

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