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Additional breakthrough came with the simultaneous discovery of 5-hydroxymethylcytosine (5hmC) and Ten eleven translocation (TET) proteins that oxidize 5 mC into 5hmC using reduced iron (Fe2+) and -ketoglutarate (-KG) as cofactors (Figure 1) (Tahiliani et al., 2009)
DSIP = Delta Sleep-Inducing Peptide, GH = growth hormone, SIRT1 = sirtuin 1, CLOCK = circadian locomotor output cycles kaput
Ferroptosis in cancer therapy: a novel approach to reversing drug resistance
10.1016/j.tins.2022.01.005 Trends Neurosci
