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Description
Shaking creates powerful shear forces that can denature, or break apart, the delicate glutathione molecule
In vitro experiments confirm that lipopolysaccharide stimulation rapidly induces the secretion of IL-6 and the profibrotic cytokine TGF-1 by macrophages (129)
Challenges comprise of standardized assessment of treatment outcomes, antioxidant selection and dosage issues, and ongoing observation and evaluation of long-term effects
The oxidative stress-induced weakening of the fibrous cap covering the plaque, due to the degradation of extracellular matrix components by matrix metalloproteinases (MMPs), is a key factor in plaque instability [75]
