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10.1186/s12943-018-0796-y Mol

This antihypertensive measure was found to be mediated by nitric oxide

By contrast, man is exposed to a variety of dietary and environmental chemicals and to a poly-pharmacy of both prescribed and self-administered medications over many years

When present, side effects are typically mild and transient, potentially including slight drowsiness if administered too early (easily resolved by timing adjustment), mild headaches during initial adaptation in some individuals (usually resolving within days), temporary vivid dreams as sleep architecture normalizes, or rare reports of mild dizziness upon waking in sensitive individuals