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This Temporal pattern-based analysis showed 660 differentially expressed proteins during the early phase (391 upregulated, 269 downregulated in Day 15), 543 during the mid phase (273 upregulated, 270 downregulated in Day 30), and 688 during the late phase (292 upregulated, 396 downregulated in Day 45) (Supplementary Table 1)
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One of the first rationally designed structures was a molecular tweezer named CLR01, which presents a particular curved structure with a negatively charged cavity
