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Non-enzymatic reactions of Sglutathionylation proceed by the thiol-disulfide exchange between protein thiol (PrSH) and oxidized glutathione (GSSG): PrSH + GSSG PrSSG + GSH

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NNMT alters Akt phosphorylation and affects the association between the transcription factor SP1 and the MMP2 promoter (50)

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It helps coordinate the complex series of events needed for tissue repair

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By targeting the HIF-1 gene and regulating its stability and activity in hypoxic conditions, gene editing can effectively alleviate the pathological manifestations of HAPH [115]

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