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Among the first recruited circulating immune cells are monocytes, which differentiate into MoMFs and, together with activated KCs, release pro-inflammatory mediators such as TGF- and activate HSCs, thereby further perpetuating inflammation and promoting fibrosis [9, 54, 78]

Dichloroacetate (DCA) can enhance metformin-induced oxidative damage with simultaneous reduce of metformin promoted lactate production through PDK1 inhibition, suggesting the innovative combinations, such as metformin and DCA, will be promising in expanding breast cancer therapies (302)