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Triptolide suppresses oral cancer cell PD-L1 expression in the interferon--modulated microenvironment in vitro, in vivo, and in clinical patients

Based on their structure, spider venom PLDs can be assigned to class I, featuring three cysteine residues, two forming a disulfide bridge, and five residues in an extended flexible loop or class II, which features four cysteine residues forming two disulfide bridges, one connecting the catalytic region to a flexible loop and reducing the size of the active site cavity (Murakami et al., 2006

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Store in a cool dry place out of direct sunlight