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Clinical studies have reported strong correlations between oxidative stress biomarkers, such as malondialdehyde (MDA), and intestinal barrier injury markers, such as I-FABP, in sepsis patients ( Mitochondria, the primary energy factories of the cell, play a central role in apoptosis mediated by mitochondrial dysfunction, which is a key driver of multiple organ dysfunction syndrome (MODS) in sepsis (Tbara et al., 2025

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The C677T variant results from a single nucleotide substitution at this position, in which cytosine is replaced by thymine resulting a conversion of alanine to valine residue 24

(1996) Lipophilicity in Drug Action and Toxicology