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Lactobacillus rhamnosus: TMAO Reduction and Systemic Odor Compounds A 2022 systematic review published in Nutrients analyzed human and animal controlled intervention studies on probiotics and plasma trimethylamine N-oxide (TMAO) levelsan important metric because elevated TMAO reflects the same metabolic pathway that, when disrupted, produces the malodorous TMA associated with fish odor syndrome

In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress

Khalil M, Shanmugam H, Abdallah H, John Britto JS, Galerati I, Gmez-Ambrosi J, Frhbeck G, Portincasa P (2022) The potential of the Mediterranean Diet to improve mitochondrial function in experimental models of obesity and metabolic syndrome

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