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Description
In cholestasis liver fibrosis models, SIRT1 inhibits the Transforming Growth Factor Beta 1 (TGF-1)/Smad pathway, reducing profibrotic markers such as TGF-, alpha-smooth muscle actin (-SMA), and collagen I, thereby decreasing HSC activation and epithelial-mesenchymal transition, slowing fibrosis progression (Pan et al., 2022
doi: 10.3389/fimmu.2022.832394 121 HuangI.PranataR
doi: 10.1186/1472-6823-14-2
J Pharm Exp Therap
