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Importantly, the disease causing I148M variant was a gain of function for the interaction with ABHD5 and inhibition of lipolysis, and could promote TAG accumulation in an ABHD5-dependent manner (70)

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Current data indicate that the vast majority of obese people treated with semaglutide and tirzepatide achieve weight losses of this magnitude (Figure 6)

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67 Hypoxia has also been shown to induce HIF1 expression in association with NFB activation

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