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Grey literature sources, including clinicaltrial.gov and ProQuest, were also searched to find potential additional trials

After mutation of the PAZ RNA-binding pocket (F294A, Y311A), trigger variants with longer internal loops induced binding and polyubiquitylation no better than did the seed-only variant, supporting the idea that together, trigger-specific RNA trajectory and binding of the vacated PAZ pocket substantially contribute to ZSWIM8 selectivity for TDMD substrates

Among such species the radical forms are removed via non-enzymatic reduction with GSH, whereas the elimination of hydroperoxides requires enzymatic catalysis by GPX and catalase

Chen HL, Wang Z, Wang ZL, Dou J, Zhou CL (2016) Improving methionine and ATP availability by MET6 and SAM2 co-expression combined with sodium citrate feeding enhanced SAM accumulation in Saccharomyces cerevisiae