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AMX0035 had shown significant slowing of disease progression and prolonged survival (40)
In a clinical study of 12 dogs with atopic dermatitis treated with azathioprine (2.2 mg/kg daily for 8 weeks) as a single agent, an increase in ALT or ALP activity was noted in the first 2 weeks in 10 (83%) of the dogs
doi: 10.1182/blood.V100.10.3832 68 DulucqSLaverdireCSinnettDKrajinovicM
As mentioned previously, the brain utilizes ~20% of whole-body oxygen consumption despite making up only 2% of body mass, making it especially vulnerable to oxidative damage and environmental toxins, but also to energy depletion [123,124]
