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Case Study 4: Marks Off-Label Use Mark, a 70-year-old Medicare beneficiary, had a unique situation where his doctor prescribed off-label B12 shots

Pan, W., et al

Its core pathogenesis involves the interplay of three key processes: immune dysregulation that is characterized by Treg dysfunction and B-cell hyperactivation, vascular endothelial injury and dysfunction, and abnormal fibroblast proliferation (226)

For example, those with severe liver or kidney impairment, unstable heart disease, or other significant systemic illnesses are typically approached carefully if considering NAD+ therapy
