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Clin Rheumatol 2018;37:683-690 10.1007/s10067-017-3893-1 [DOI] [PubMed] [Google Scholar] 116

As a constituent of simulated plasma protein mixture for Raman spectra analysis

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After applying chrysin to early hepatocellular carcinoma cells induced by N-nitrosodiethylamine (DEN), the expression of COX-2 and NF-B was significantly reduced at both mRNA and protein levels, similarly, the level of the anti-apoptotic marker Bcl-xL was decreased, whereas the expression of p53, Bax, and caspase-3 was elevated, which inhibited DEN-induced hepatocellular carcinoma cell proliferation and apoptosis (Khan et al., 2011b