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Additionally, many patients abandon GLP-1 medications due to intolerable side effects, including nausea, vomiting, diarrhea, and fatigue
However, this enhanced fertility creates an important safety consideration, as these medications are not recommended during pregnancy
Only 0.5% of participants stopped Mazdutide due to adverse events compared to 11.2% for Retatrutide at maximum doses
GLP-1 exists in two equipotent circulating peptides: GLP-1 (737) and GLP-1 (736) amide (27), with GLP-1 (736) amide being more abundant in the circulation after a meal (28)
