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Essentially, we will recommend an increase caloric intake for a week and reassess with our coaching team to reset hormonal and metabolic responses, preventing the slowdown associated with prolonged calorie restriction

Any modification to standard continuous treatment should involve close medical monitoring

However, practical factors such as cost, patient adherence, and tolerability often make an add-on approach more feasible in real-world settings

Through downregulating monocyte chemoattractant protein-1 expression, semaglutide treatment, an FDA-approved GLP-1 RA medicine targeting Type II diabetes mellitus (T2DM) (Christou et al., 2019), inhibited monocyte migration and infiltration from the circulatory system to inflammatory regions (Pontes-da-Silva et al., 2022)