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The oral segment is projected to witness the fastest CAGR from 2025 to 2032, driven by the growing demand for needle-free alternatives and the launch of oral GLP-1 receptor agonists such as Rybelsus (oral semaglutide) and future pipeline products such as orforglipron

The gradual dose escalation helps minimize gastrointestinal side effects, which are among the most common adverse reactions reported in clinical studies

doi: 10.3389/fmed.2025.1638981 Received 31 May 2025 Accepted 14 August 2025 Published 10 September 2025 Volume 12 - 2025 Edited by Iain Brownlee, Northumbria University, United Kingdom Reviewed by Qianqian Zhang, Anhui University of Chinese Medicine, China Ion Hobai, Massachusetts General Hospital and Harvard Medical School, United States Updates Copyright 2025 Ukwade, Hernandez, Modi, Raza, Siegel, Nwachukwu, Sarraf, Memon, Booth, Cooper, Boulay and Mutlu